ABSTRACT
ABSTRACT Objective The goal of this study was evaluate the conicity index (C index) in women and its association with hypertension (SAH) and diabetes mellitus (DM). Subjects and methods This was a cross-sectional study, with 573 women between 20 and 59 years of age. After analysis of clinical and demographic characteristics, anthropometric variables were measured and used to calculate the C index. Plasma glucose and lipid profile were evaluated by standard methods. The analysis of the results was based on logistic regression and the odds ratio (OR) was calculated, which was used to assess the association of the variable outcome with the variable exposure using two logistic regression models that tested the possible influence of the C index in the chance of developing SAH or DM. A confidence interval of 95% was used. Results In the crude and adjusted models, the OR confirmed the association of the C index with DM and SAH. Compared with women that showed C index p < 75, the risk of women with C index (p ≥ 75) developing DM and SAH was 1.72 and 1.75, respectively. Results demonstrated that the negative impact of age on these associations significantly raised the odds of women having DM and SAH. The high C index was also linked to low HDL-C. Conclusion The C index is an important tool in estimating the risk of diabetes and hypertension in women. Besides, high C indexes are negatively associated with HDL-C, an important lipid marker related to cardiovascular risk.
Subject(s)
Humans , Female , Adult , Middle Aged , Young Adult , Diabetes Mellitus/etiology , Body Fat Distribution , Obesity, Abdominal/complications , Hypertension/etiology , Reference Values , Blood Glucose/analysis , Brazil , Cardiovascular Diseases/etiology , Cardiovascular Diseases/physiopathology , Logistic Models , Cholesterol/blood , Cross-Sectional Studies , Statistics, Nonparametric , Diabetes Mellitus/physiopathology , Diabetes Mellitus/blood , Hypertension/bloodABSTRACT
Objective:This study aimed to evaluate the association between Lipid Accumulation Product and biochemical markers and verify how it is affected by sex, age and medication use. Methods:This is a cross-sectional study including biochemical, clinical, demographic and anthropometric data from 617 individuals, both sexes, between 20 and 59 years old, without previous cardiovascular event.Data was collected between 2000 and 2014. The influence of Lipid Accumulation Product on the biochemical variables levels was assessed by multiple linear regression analysis for men and women. Statistical analyzes were performed using SPSS version 20.0 software at significance level of p<0.05. Results:Both sexes presented overweight and increased waist circumference.The median Lipid Accumulation Product was 57.8 and men showed higher values than women. In both sexes, the Lipid Accumulation Product significantly influenced the total cholesterol and high-density lipoprotein levels and these results were adjustment variables (age and hypolipidemic agents) independent. Conclusions:Results showed that Lipid Accumulation Product was associated with low HDL levels and increased concentrations of TC regardless of sexes, age and lipid-lowering drugs
Objetivo: Avaliar a associação do Produto da Acumulação Lipídica com marcadores bioquímicos e verificar a influência do sexo, idade e uso de medicamentos sobre as associações. Métodos: O estudo é de corte transversal com 617 indivíduos de ambos os sexos e idade entre 20 e 59 anos, sem registro de evento cardiovascular prévio. Dados bioquímicos, clínicos, demográficos e antropométricos foram coletados entre os anos de 2000 e 2014. Para avaliar a influência do Produto da Acumulação Lipídica na concentração das variáveis bioquímicas, foram realizadas análises de regressão linear múltipla para homens e mulheres. As análises estatísticas foram feitas no programa SPSS versão 20.0 considerando um valor de significância p<0,05. Resultados: Ambos os sexos apresentaram excesso de peso e circunferência da cintura elevada. A mediana do Produto da Acumulação Lipídica foi 57,8 sendo que os homens apresentaram valores superiores às mulheres. Em ambos os sexos, o Produto da Acumulação Lipídica influenciou de maneira significativa as concentrações de colesterol total e colesterol associado à lipoproteína de alta densidade e estes resultados foram independentes das variáveis de ajuste (idade e medicamentos hipolipemiantes). Conclusão: Os resultados obtidos mostram que o Produto da Acumulação Lipídica se associou com baixos valores de HDL e elevada concentração de CT, independentemente do sexo, idade e medicamentos hipolipemiantes